반응 #49811

반응 방정식

Methyl N-(6-chloro-3-nitro-2-pyridyl)-2-aminoisobutyrate

hydrogen

hydrogen

→

compound

수율 61.2%

6-Chloro-3,3-dimethyl-3,4-dihydro-1,4,5-triazanaphthalen-2(1H)-one

수율 61.2%

용매

methanol

반응 조건

후처리

1. 1
   여과the catalyst was filtered off with suction
2. 2
   농축the filtrate was concentrated
3. 3
   기타chromatographed on silica gel (ethyl acetate/heptane=1:2)

실험 절차

Methyl N-(6-chloro-3-nitro-2-pyridyl)-2-aminoisobutyrate (4.0 g, 14.6 mmol) was hydrogenated in 250 ml of methanol with Raney nickel catalysis under 1 atm of hydrogen. After hydrogen uptake ceased, the catalyst was filtered off with suction, and the filtrate was concentrated and chromatographed on silica gel (ethyl acetate/heptane=1:2). 1.89 g (61%) of the compound of Example 15, of melting point 229° C., were obtained.

출처