반응 #49807

반응 방정식

Compound A

N-(6-Chloro-3-nitro-2-pyridyl)-alanine methyl ester

→

pure product

수율 24.3%

(3S)-6-Chloro-3-methyl-3,4-dihydro-1,4,5-triazanaphthalen-2(1H)-one

수율 24.3%

용매

methanol

hydrogen

hydrogen

반응 조건

후처리

1. 1
   여과the catalyst was filtered off with suction
2. 2
   기타the solvent was removed in vacuo

실험 절차

Compound A (9.0 g, 0.05 mol) was dissolved in 200 ml of methanol and hydrogenated with Raney nickel catalysis under 1 atm of hydrogen. After hydrogen uptake ceased, the catalyst was filtered off with suction, and the solvent was removed in vacuo. The solid product was stirred with diethyl ether, resulting in 2.4 g of pure product (melting point 236°-237° C.).

출처