반응 #49751

반응 방정식

cyclopentyl bromide

Ethyl N-(2-fluoro-4-chloro-5-methoxycarbonyloxyphenyl)carbamate

potassium carbonate

hydrochloric acid

→

ethyl N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)carbamate

용매

ethanol

반응 조건

후처리

1. 1
   온도while refluxing
2. 2
   기타After completion of the reaction
3. 3
   추출extracted with ethyl acetate (50 ml×3 times)
4. 4
   기타The organic layer was dried
5. 5
   농축concentrated under reduced pressure

실험 절차

Ethyl N-(2-fluoro-4-chloro-5-methoxycarbonyloxyphenyl)carbamate (1.45 g, 4.97 mmol) prepared by the process described in Reference Example 1 and a solution of potassium carbonate (1.03 g, 7.46 mmol) in ethanol (5.0 ml) were stirred for 1 hour while refluxing, and then cyclopentyl bromide (1.11 g, 7.46 mmol) was added thereto, followed by further stirring for 2 hours. After completion of the reaction, the mixture was poured into 1N hydrochloric acid (50 ml), and extracted with ethyl acetate (50 ml×3 times). The organic layer was dried, and concentrated under reduced pressure to obtain ethyl N-(2-fluoro-4-chloro-5-cyclopentyloxyphenyl)carbamate as grey white crystals (1.41 g, 4 69 mmol 94.4% yield) The spectral data and the like are as shown in Reference Example 1.

출처