반응 #49713

반응 방정식

8-chlorooctan-1-ol

sodium iodide

→

8-iodooctan-1-ol

수율 90.0%

용매

acetone

반응 조건

후처리

1. 1
   온도was heated
2. 2
   온도at reflux overnight
3. 3
   여과The mixture was filtered
4. 4
   기타to remove
5. 5
   기타precipitated sodium chloride
6. 6
   기타the filtrate was evaporated in vacuo
7. 7
   기타the residue partitioned between water (200 ml) and ether (200 ml)
8. 8
   기타The ether layer was separated
9. 9
   세척washed with 1M sodium thoisulfate solution (200 ml)
10. 10
    건조dried over anhydrous magnesium sulfate
11. 11
    여과Filtration, and solvent removal in vacuo

실험 절차

A mixture of 8-chlorooctan-1-ol (25 g, 152 mmol) and sodium iodide (125 g, 834 mmol) in acetone (500 ml) was heated at reflux overnight. The mixture was filtered to remove precipitated sodium chloride, the filtrate was evaporated in vacuo, and the residue partitioned between water (200 ml) and ether (200 ml). The ether layer was separated, washed with 1M sodium thoisulfate solution (200 ml), and dried over anhydrous magnesium sulfate. Filtration, and solvent removal in vacuo, afforded 8-iodooctan-1-ol as a colorless oil (34.85 g, 90%).

출처