반응 #496888

반응 방정식

Compound 24

N,N,2-trimethylbenzo[d]thiazole-6-sulfonamide

1-4-butane sultone

→

Compound 26

수율 92.0%

4-(6-(N,N-dimethylsulfamoyl)-2-methylbenzo[d]thiazole-3-ium-3-yl)butane-1-sulfonate

수율 92.0%

반응 조건

후처리

1. 1
   온도to cool to room temperature
2. 2
   기타the resulting mass was triturated with ethyl acetate (40 ml) until a pink solid
3. 3
   기타separated
4. 4
   기타The solid was collected by centrifugation
5. 5
   세척washed with ethyl acetate
6. 6
   기타dried under vacuum

실험 절차

A mixture of Compound 24 (2.55 g, 10.0 mmol) from step (a) of Example 27 and 1-4-butane sultone (2.98 g, 21.9 mmol) was heated in a pressure tube at 160° C. for 17 hours. The mixture was allowed to cool to room temperature, and the resulting mass was triturated with ethyl acetate (40 ml) until a pink solid separated. The solid was collected by centrifugation, washed with ethyl acetate and dried under vacuum to yield 3.58 g (92%) of Compound 26 with the structure:

출처