반응 #49654

반응 방정식

4-(2-aminoethyl)morpholine

ethyl formate

→

title compound

수율 100.0%

4-[2(N-Formylamino)ethyl]morpholine

수율 100.0%

반응 조건

후처리

1. 1
   workup.DISTILLATIONVacuum distillation
2. 2
   기타gave 11.46 g (100% yield) of a clear, colorless liquid (bp0.3 118°-120° C.)

실험 절차

The procedure of B. V. Cheney et al. [J. Med. Chem., 28, 1853-1864 (1985)) was used. A solution of 4-(2-aminoethyl)morpholine (1.00 g, 76.8 mmol) and ethyl formate (213 mL, 2640 mmol) was refluxed overnight under an atmosphere of nitrogen. Vacuum distillation gave 11.46 g (100% yield) of a clear, colorless liquid (bp0.3 118°-120° C.). The 1H NMR spectral data were consistent with the structure of the title compound.

출처