반응 #49600

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4-chloro-5-hydroxy-7-iodoisoindolinone

potassium carbonate

(4-bromo-2-methyl-2-butoxy)triethylsilane

→

4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone

수율 35.0%

용매

DMF

반응 조건

후처리

1. 1
   기타followed by purification by flash column chromatography (chloroform/methanol=99/1)

실험 절차

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (70.8 mg, 0.229 mmol) was dissolved in DMF (2.1 mL), and the solution was treated with potassium carbonate (94.8 mg, 0.686 mmol), tetrabutylammonium iodide (8.5 mg, 0.023 mmol) and (4-bromo-2-methyl-2-butoxy)triethylsilane (193 mg, 0.686 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1) to obtain 4-chloro-5-[3-methyl-3-(triethylsiloxy)butoxy]-7-iodoisoindolinone (40.7 mg, yield 35%).

출처