반응 #49594

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4-chloro-5-hydroxy-7-iodoisoindolinone

potassium carbonate

tert-butyl(3-bromopropoxy)dimethylsilane

→

4-chloro-5-[3-(tert-butyldimethylsiloxy)propoxy]-7-iodoisoindolinone

수율 79.7%

용매

DMF

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후처리

1. 1
   기타followed by purification by flash column chromatography (chloroform/methanol=99/1, 19/1)

실험 절차

In a similar manner to Step 1 of Example 429, 4-chloro-5-hydroxy-7-iodoisoindolinone (100 mg, 0.323 mmol) was dissolved in DMF (3.0 mL), and the solution was treated with potassium carbonate (134 mg, 0.969 mmol), tetrabutylammonium iodide (11.8 mg, 0.032 mmol) and tert-butyl(3-bromopropoxy)dimethylsilane (0.112 mL, 0.485 mmol), followed by purification by flash column chromatography (chloroform/methanol=99/1, 19/1) to obtain 4-chloro-5-[3-(tert-butyldimethylsiloxy)propoxy]-7-iodoisoindolinone (124 mg, yield 79%).

출처