반응 #495242

반응 방정식

Metformin hydrochloride

metformin hydrochloride

→

Metformin

용매

water

반응 조건

후처리

1. 1
   기타dried in the same device
2. 2
   workup.ADDITIONPre-sieved magnesium stearate is added to the obtained blend
3. 3
   기타is obtained

실험 절차

Metformin hydrochloride is screened through 1 mm sieve. Screened metformin hydrochloride is granulated in a fluid bed granulator with a solution of povidone in demineralized water and dried in the same device. The dried granulate is screened through a 1 mm sieve. The obtained granulate, microcrystalline cellulose and hydroxypropylmethylcellulose are homogenously blended in a bin blender. Pre-sieved magnesium stearate is added to the obtained blend and blended in a bin blender so that the final blend is obtained. The final blend is compressed into a bilayer tablet as disclosed in Examples 11 in 12.

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