반응 #4950

반응 방정식

Dimethylamine

epichlorohydrin

methylamine

→

1-dimethylamino-3-methylamino-2-propanol hydrochloride

수율 84.0%

용매

methanol

반응 조건

후처리

1. 1
   workup.STIRRINGStirring
2. 2
   기타for one hour
3. 3
   기타room temperature overnight
4. 4
   기타The solvents were evaporated

실험 절차

Dimethylamine 22.6 g, 40% solution (0.2 mole) was added dropwise to a solution of 16 ml of epichlorohydrin (0.2 mole) in 100 ml of methanol at 5° C. stirring in an ice bath. After two hours at 5° C. a chilled solution of 86 ml methylamine of 40% solution (1 mole) was poured into the reaction mixture. Stirring was continued in ice bath for one hour and then room temperature overnight. The solvents were evaporated and the clear oil was pumped under vacuum at 75° C. for 1.5 hr to give 28.23 g (~84% yield) of 1-dimethylamino-3-methylamino-2-propanol hydrochloride (I) as the main product.

출처