반응 #49468
ord-67c101f9644c4906b0a4a7cbf1725fa0
반응 방정식
반응물
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1기타followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1)
- 2기타to obtain
실험 절차
In a similar manner to Step 4 of Example 140, a mixture of 7-amino-4-methylisoindolinone and 7-aminoisoindolinone (10/1, 57.4 mg, 0.357 mmol) was dissolved in acetonitrile (4.6 mL), and the solution was treated with potassium iodide (78 mg, 0.47 mmol), copper iodide (90 mg, 0.47 mmol), iodine (120 mg, 0.471 mmol) and tert-butyl nitrate (0.128 mL, 1.07 mmol), followed by purification by preparative thin-layer chromatography (chloroform/acetonitrile=5/1) to obtain a mixture of 7-iodo-4-methylisoindolinone and 7-iodoisoindolinone (44.8 mg, ratio 10/1, yield 50%).