반응 #49446

반응 방정식

4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

triethylamine

1-naphthalenesulfonyl chloride

→

4-(1-naphthalenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

수율 61.1%

용매

acetonitrile

반응 조건

실험 절차

In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0358 g, 0.0776 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0650 mL, 0.465 mmol) and 1-naphthalenesulfonyl chloride (0.0530 g, 0.233 mmol) to obtain 4-(1-naphthalenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0309 g, yield 61%).

출처