반응 #494370

반응 방정식

cyclohexene oxide

sodium azide

acetone

→

2-azidocyclohexanol

용매

water

반응 조건

후처리

1. 1
   온도The mixture was cooled to rt
2. 2
   농축concentrated in vacuo to 50 mL
3. 3
   추출extracted 3× with dichloromethane
4. 4
   세척The combined organic fractions were washed 2× with water
5. 5
   건조dried over sodium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated in vacuo

실험 절차

A solution of cyclohexene oxide (10.1 g, 103 mmol) and sodium azide (16.7 g, 257 mmol) in 100 mL of a 1:1 mixture of acetone:water was heated to reflux at 75° C. for 14 h. The mixture was cooled to rt, concentrated in vacuo to 50 mL, and extracted 3× with dichloromethane. The combined organic fractions were washed 2× with water, dried over sodium sulfate, filtered, and concentrated in vacuo to provide 2-azidocyclohexanol that gave a proton NMR spectra consistent with theory.

출처