반응 #494062

반응 방정식

4-methoxycarbonylphenylboronic acid

2-propanol

(1R,3aS,5aR,5bR,7aR,11aR,11bR,13bR)-benzyl 5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-9-(trifluoromethylsulfonyloxy)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylate

sodium carbonate monohydrate

→

(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR 13bR)-benzyl 9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylate

수율 68.4%

용매

water

dioxane

반응 조건

후처리

1. 1
   기타The flask was attached to a reflux condenser
2. 2
   기타was flushed with N2
3. 3
   온도was heated
4. 4
   온도to reflux overnight
5. 5
   온도After heating the mixture for 14.5 h
6. 6
   workup.ADDITIONwas diluted with water (75 mL)
7. 7
   추출The mixture was extracted with ethyl acetate (3×75 mL)
8. 8
   세척washed with brine
9. 9
   건조The combined organic layers were dried with MgSO4
10. 10
    여과filtered
11. 11
    농축concentrated under reduced pressure
12. 12
    기타was purified by Biotage flash chromatography
13. 13
    workup.ADDITIONThe fractions containing the expected product
14. 14
    농축concentrated under reduced pressure

실험 절차

To a round bottom flask containing a solution of (1R,3aS,5aR,5bR,7aR,11aR,11bR,13bR)-benzyl 5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-9-(trifluoromethylsulfonyloxy)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylate (6.21 g, 9.18 mmol) in dioxane (25 mL) was added 2-propanol (25 mL) and water (15 mL) followed by sodium carbonate monohydrate (3.42 g, 27.5 mmol), 4-methoxycarbonylphenylboronic acid (2.478 g, 13.77 mmol), and tetrakis(triphenylphosphine)palladium(0) (0.318 g, 0.275 mmol). The flask was attached to a reflux condenser, was flushed with N2, and was heated to reflux overnight. After heating the mixture for 14.5 h, it was cooled to rt and was diluted with water (75 mL). The mixture was extracted with ethyl acetate (3×75 mL) and washed with brine. The combined organic layers were dried with MgSO4, filtered, and concentrated under reduced pressure. The residue was adsorbed to silica gel and was purified by Biotage flash chromatography using a 0-20% EtOAc in hexanes gradient. The fractions containing the expected product was combined and concentrated under reduced pressure. The expected product, (1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR 13bR)-benzyl 9-(4-(methoxycarbonyl)phenyl)-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysene-3a-carboxylate (4.16 g, 6.28 mmol, 68.4% yield), was isolated as a white foam. 1H NMR (500 MHz, CHLOROFORM-d) δ ppm 0.82 (s, 3H), 0.87-1.75 (m, 17H), 0.91 (s, 3H), 0.92 (s, 3H), 0.95 (s, 3H), 0.97 (s, 3H), 1.69 (s, 3H), 1.82-1.95 (m, 2H), 2.09 (dd, J=17.24, 6.26 Hz, 1H), 2.20-2.32 (m, 2H), 3.04 (td, J=10.91, 4.73 Hz, 1H), 3.90 (s, 3H), 4.60 (s, 1H), 4.73 (d, J=1.83 Hz, 1H), 5.07-5.19 (m, 2H), 5.28 (dd, J=6.10, 1.83 Hz, 1H), 7.19 (d, J=8.24 Hz, 2H), 7.29-7.40 (m, 5H), 7.92 (d, J=8.24 Hz, 2H).

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