반응 #49398

반응 방정식

triethylamine

4-chloro-7-iodoisoindolinone

1-(tert-butoxycarbonyl)-5-cyanoindole-2-boronic acid

→

4-chloro-7-[1-(tert-butoxycarbonyl)-5-cyanoindol-2-yl]isoindolinone

수율 42.9%

용매

hexane ethyl acetate

acetonitrile

반응 조건

후처리

1. 1
   기타synthesized in a similar manner to the method

실험 절차

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (68.4 mg, 0.230 mmol) was dissolved in acetonitrile (1.4 mL), and the solution was treated with 1-(tert-butoxycarbonyl)-5-cyanoindole-2-boronic acid (100 mg, 0.350 mmol) synthesized in a similar manner to the method described in Journal of Organic Chemistry, 2002, vol. 67, p. 7551, palladium acetate (4.1 mg, 0.018 mmol) and triethylamine (0.321 mL, 2.30 mmol), followed by purification by preparative thin-layer chromatography (hexane/ethyl acetate=1/1) to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-5-cyanoindol-2-yl]isoindolinone (40.2 mg).

출처