반응 #49384
ord-3a4194fa02704c5cae6b287a0ac883f5
반응 방정식
용매
반응 조건
상세 조건
See reaction.notes.procedure_details.
후처리
- 1추출extracted with ethyl acetate
- 2세척The organic layer was washed with saturated brine
- 3건조dried over anhydrous sodium sulfate
- 4기타The solvent was evaporated under reduced pressure
- 5기타the residue was purified by slurry
실험 절차
3-Amino-6-[1-(tert-butoxycarbonyl)indol-2-yl]phtalimide (300 mg, 0.795 mmol) was dissolved in ethanol (21 mL), and the solution was added with iodine (242 mg, 0.954 mmol) and silver sulfate (248 mg, 0.795 mmol), followed by stirring at room temperature for 1.3 hours. The reaction mixture was added with water and extracted with ethyl acetate. The organic layer was washed with saturated brine and dried over anhydrous sodium sulfate. The solvent was evaporated under reduced pressure and the residue was purified by slurry using chloroform to obtain 3-amino-6-[1-(tert-butoxycarbonyl)-3-iodoindol-2-yl]phtalimide (326 mg, yield 82%).