반응 #49381

반응 방정식

triethylamine

4-chloro-7-iodoisoindolinone

→

Compound 156

수율 164.2%

4-Chloro-7-(1-methylindol-2-yl)isoindolinone

수율 164.2%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타followed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1)

실험 절차

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (84.0 mg, 0.286 mmol) was dissolved in acetonitrile (3 mL), and the solution was treated with Compound BK (100 mg, 0.571 mmol), palladium acetate (5.2 mg, 0.023 mmol) and triethylamine (0.400 mL, 2.87 mmol), followed by purification by flash column chromatography (hexane/ethyl acetate=7/3, 3/2, 1/1) to obtain Compound 156 (69.7 mg, yield 82%).

출처