반응 #49373

반응 방정식

7-amino-4-bromoisoindolinone

2-(tributylstannyl)thiophene

→

7-amino-4-(thiophen-2-yl)isoindolinone

수율 54.0%

용매

THF

반응 조건

후처리

1. 1
   기타followed by purification by preparative thin-layer chromatography (chloroform/methanol=12/1)

실험 절차

In a similar manner to Step 1 of Example 10, 7-amino-4-bromoisoindolinone (404 mg, 1.78 mmol) was dissolved in THF (20 mL), and the solution was treated with 2-(tributylstannyl)thiophene (1.13 mL, 3.56 mmol) and bis(triphenylphosphine)dichloropalladium (100 mg, 0.142 mmol), followed by purification by preparative thin-layer chromatography (chloroform/methanol=12/1) to obtain 7-amino-4-(thiophen-2-yl)isoindolinone (220 mg, yield 54%).

출처