반응 #49372

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4-methoxymethoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

trifluoroacetic acid

triethylsilane

→

4-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

수율 59.0%

4-methoxymethoxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

수율 27.0%

용매

nitromethane

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후처리

1. 1
   기타followed by purification by flash column chromatography (chloroform/methanol=100/0, 99/1)

실험 절차

In a similar manner to Step 4 of Example 16, 4-methoxymethoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (500 mg, 1.10 mmol) was dissolved in nitromethane (25 mL), and the solution was treated with trifluoroacetic acid (0.525 mL, 6.82 mmol) and triethylsilane (0.527 mL, 3.30 mmol), followed by purification by flash column chromatography (chloroform/methanol=100/0, 99/1) to obtain 4-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (257 mg, yield 59%) and 4-methoxymethoxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (131 mg, yield 27%).

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