반응 #49360

반응 방정식

3-acetoxybenzoic acid

EDCI

HOBT monohydrate

cumylamine

→

3-acetoxy-N-(1-methyl-1-phenylethyl)benzamide

수율 73.1%

용매

DMF

반응 조건

후처리

1. 1
   기타followed by purification by slurry

실험 절차

In a similar manner to Step 1 of Example 137, 3-acetoxybenzoic acid (7.92 g, 44.0 mmol) was dissolved in DMF (45 mL), and the solution was treated with EDCI (12.7 g, 66.0 mmol), HOBT monohydrate (3.37 g, 22.0 mmol) and cumylamine (14.2 mL, 96.8 mmol), followed by purification by slurry using diisopropylether to obtain 3-acetoxy-N-(1-methyl-1-phenylethyl)benzamide (9.57 g, yield 73%).

출처