반응 #49354

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4-methoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone

TMEDA

sec-butyllithium hexane

iodine

→

4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone

수율 77.0%

용매

THF

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후처리

1. 1
   기타followed by purification by flash column chromatography (hexane/ethyl acetate=9/1, 7/3)

실험 절차

In a similar manner to Step 3 of Example 16, 4-methoxy-3-hydroxy-2-(1-methyl-1-phenylethyl)isoindolinone (3.55 g, 11.9 mmol) was dissolved in THF (140 mL), and the solution was treated with TMEDA (4.00 mL, 26.2 mmol), sec-butyllithium-hexane solution (0.99 mol/L, 26.4 mL, 26.2 mmol) and iodine (3.62 g, 14.3 mmol), followed by purification by flash column chromatography (hexane/ethyl acetate=9/1, 7/3) to obtain 4-methoxy-3-hydroxy-7-iodo-2-(1-methyl-1-phenylethyl)isoindolinone (3.88 g, yield 77%).

출처