반응 #49334

ord-5c558c79d2e94fe5bc0da5929fb555d3

반응 방정식

CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(C=O)ccc21
4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone
OC1(c2ccccc2)CCNCC1
4-hydroxy-4-phenylpiperidine
CC(=O)O[BH-](OC(C)=O)OC(C)=O.[Na+]
sodium triacetoxyborohydride
CC(C)(C)OC(=O)n1c(-c2ccc(Cl)c3c2C(=O)NC3)cc2cc(CN3CCC(O)(c4ccccc4)CC3)ccc21
4-chloro-7-[1-(tert-butoxycarbonyl)-5-(4-hydroxy-4-phenylpiperidinomethyl)indol-2-yl]isoindolinone

반응 조건

상세 조건
See reaction.notes.procedure_details.

실험 절차

In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 4-hydroxy-4-phenylpiperidine (35 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-5-(4-hydroxy-4-phenylpiperidinomethyl)indol-2-yl]isoindolinone.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07745641B2uspto-grants-2010_06