반응 #49328
ord-bc2e9bba57144aaa80460cf22207043d
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반응 조건
상세 조건
See reaction.notes.procedure_details.
실험 절차
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with 2-fluoroethylamine hydrochloride (20 mg, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-{1-(tert-butoxycarbonyl)-5-[(2-fluoroethyl)aminomethyl]indol-2-yl}isoindolinone.