반응 #49327
ord-8942cb62d85f48b5893084ffef4fd040
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상세 조건
See reaction.notes.procedure_details.
실험 절차
In a similar manner to Step 1 of Example 56, 4-chloro-7-[1-(tert-butoxycarbonyl)-5-formylindol-2-yl]isoindolinone (20.0 mg, 0.0487 mmol) was dissolved in dichloromethane (0.5 mL). The solution was treated with thiophene-2-ethylamine (0.023 mL, 0.20 mmol) and sodium triacetoxyborohydride (32 mg, 0.15 mmol) to obtain 4-chloro-7-[1-(tert-butoxycarbonyl)-5-(2-(thiophen-2-yl)ethylaminomethyl]indol-2-yl)isoindolinone.