반응 #4930

반응 방정식

dimethylamine

2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one

dimethylamine

→

2-[2-(Dimethylamino)ethyl]-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one dihydrochloride

반응 조건

후처리

1. 1
   기타to evaporate
2. 2
   기타the residue was partitioned between chloroform and dilute sodium hydroxide
3. 3
   농축The chloroform layer was concentrated
4. 4
   workup.DISSOLUTIONthe residue, the free base of the title compound, was dissolved in isopropyl alcohol
5. 5
   기타reacted with hydrogen chloride

실험 절차

A solution of 1.5 g (0.0058 mole) of 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-thiazepin-5(4H)-one in 20 ml of dimethylamine was stirred at 25° C. in a sealed container for 72 hr. The excess dimethylamine was allowed to evaporate and the residue was partitioned between chloroform and dilute sodium hydroxide. The chloroform layer was concentrated and the residue, the free base of the title compound, was dissolved in isopropyl alcohol and reacted with hydrogen chloride. The resulting hydrochloride salt weighted 1.5 g (77%), m.p.>250° C.

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