반응 #49289

반응 방정식

7-[1-(tert-butoxycarbonyl)-5-carboxyindol-2-yl]-4-chloroisoindolinone

EDCI

HOBT monohydrate

1-(tert-butoxycarbonyl)piperazine

→

4-chloro-7-(1-(tert-butoxycarbonyl)-5-[-4-(tert-butoxycarbonyl)piperazin-1-ylcarbonyl]indol-2-yl)isoindolinone

수율 83.0%

용매

water

DMF

반응 조건

후처리

1. 1
   여과the precipitated solid was collected by filtration
2. 2
   세척washed with water
3. 3
   기타dried under reduced pressure

실험 절차

In a similar manner to Example 20, 7-[1-(tert-butoxycarbonyl)-5-carboxyindol-2-yl]-4-chloroisoindolinone (37.8 mg, 0.0886 mmol) was dissolved in DMF (1 mL), and the solution was treated with EDCI (34 mg, 0.18 mmol), HOBT monohydrate (12 mg, 0.089 mmol) and 1-(tert-butoxycarbonyl)piperazine (66 mg, 0.35 mmol). The mixture was added with water and the precipitated solid was collected by filtration, washed with water and then dried under reduced pressure to obtain 4-chloro-7-(1-(tert-butoxycarbonyl)-5-[-4-(tert-butoxycarbonyl)piperazin-1-ylcarbonyl]indol-2-yl)isoindolinone (43.5 mg, yield 83%).

출처