반응 #49287

반응 방정식

4-chloro-7-iodoisoindolinone

1-(tert-butoxycarbonyl)indol-2-boronic acid

tri(o-tolyl)phosphine

triethylamine

→

4-chloro-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone

수율 44.0%

용매

acetonitrile

반응 조건

후처리

1. 1
   기타followed by purification by preparative thin-layer chromatography (chloroform/methanol=30/1)

실험 절차

In a similar manner to Step 2 of Example 1, 4-chloro-7-iodoisoindolinone (100 mg, 0.341 mmol) was dissolved in acetonitrile (7 mL), and the solution was treated with 1-(tert-butoxycarbonyl)indol-2-boronic acid (178 mg, 0.682 mmol), palladium acetate (6.1 mg, 0.027 mmol), tri(o-tolyl)phosphine (17 mg, 0.055 mmol) and triethylamine (0.475-mL, 3.41 mmol), followed by purification by preparative thin-layer chromatography (chloroform/methanol=30/1) to obtain 4-chloro-7-(1-(tert-butoxycarbonyl)indol-2-yl)isoindolinone (57 mg, yield 44%).

출처