반응 #4923

ord-c7bfc234f1744f32ad7ffb0232bfef78

반응 방정식

O=C1c2ccccc2OC(CCCl)CN1Cc1ccccc1
4-benzyl-2-(2-chloroethyl)-2,3-dihydro-1,4-benzoxazepin-5(4H)-one
CNC
dimethylamine
CN(C)CCC1CN(Cc2ccccc2)C(=O)c2ccccc2O1.O
title compound
CN(C)CCC1CN(Cc2ccccc2)C(=O)c2ccccc2O1.O
4-Benzyl-2-[2-(dimethylamino)ethyl]-2,3-dihydro-1,4-benzoxazepin-5(4H)-one monohydrate

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타were reacted

실험 절차

Following the procedure of Example 1, 4-benzyl-2-(2-chloroethyl)-2,3-dihydro-1,4-benzoxazepin-5(4H)-one and dimethylamine were reacted and the free base of the title compound was obtained in the concentrated residue. Recrystallization from ethanol-water gave the product, m.p. 75°-77° C.

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US04727152uspto-grants-1988_02