반응 #49218

반응 방정식

3-(methoxycarbonyl)benzoic acid

HATU

dipropylamine

( 1 )

(2R,4R)-1-(tert-butoxycarbonyl)-4-hydroxypyrrolidine-2-carboxylic acid

Methyl 3-(dipropylcarbamoyl)benzoate

→

title compound

3-(dipropylcarbamoyl)benzoic acid

용매

DMF

Ethyl acetate

반응 조건

후처리

1. 1
   세척the mixture was washed with H2O
2. 2
   기타dried
3. 3
   농축concentrated

실험 절차

Step E (1): Methyl 3-(dipropylcarbamoyl)benzoate. To a solution of 3-(methoxycarbonyl)benzoic acid (6.7 g, 37.2 mmol) in DMF (60 mL) was added HATU (17.0 g, 44.7 mmol) and dipropylamine (9.4 g, 93 mmol) and the reaction mixture was stirred at rt overnight. Ethyl acetate (600 mL) was added and the mixture was washed with H2O, dried and concentrated to give the title compound was used in the next step without purification.

출처