반응 #49181

반응 방정식

Compound 30

(6-{2-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-hydroxy-pyrrolidin-1-yl}-hexyl)-carbamic acid benzyl ester

→

compound 31

수율 93.0%

1-(6-Amino-hexyl)-5-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-pyrrolidin-3-ol

수율 93.0%

용매

ethyl acetate

반응 조건

후처리

1. 1
   기타purged with argon
2. 2
   workup.ADDITIONTo the solution was added 10% palladium on carbon (2 g)
3. 3
   기타The flask was purged with hydrogen 2 times
4. 4
   여과The reaction mixture was filtered through a pad of Celite
5. 5
   세척washed with ethyl acetate
6. 6
   농축The combined organic layer was concentrated under reduced pressure

실험 절차

Compound 30 (6.52 g, 10 mmol) was dissolved in ethyl acetate (100 mL) and purged with argon. To the solution was added 10% palladium on carbon (2 g). The flask was purged with hydrogen 2 times and stirred further at room temperature under hydrogen atmosphere for overnight. The disappearance of the starting material was confirmed by the TLC. The reaction mixture was filtered through a pad of Celite and washed with ethyl acetate. The combined organic layer was concentrated under reduced pressure to afford compound 31 (4.8 g, 93%) as white solid. This was used as such for the next step.

출처