반응 #491389

반응 방정식

2-amino-1-phenyl-ethanol

Compound 2

4-[3-(4-Dimethylamino-benzyl)-ureido]-N-hydroxy-butyramide

3-amino-propionic acid benzyl ester toluene-4-sulfonic acid

4-dimethylaminobenzylamine dihydrochloride

→

Compound 14

N-hydroxy-3-[3-(2-hydroxy-2-phenyl-ethyl)-ureido]-propionamide

반응 조건

실험 절차

Compound 14 was prepared using the methodology described for the preparation of Compound 2, by substituting 4-amino-butyric acid benzyl ester toluene-4-sulfonic acid with 3-amino-propionic acid benzyl ester toluene-4-sulfonic acid and 4-dimethylaminobenzylamine dihydrochloride with 2-amino-1-phenyl-ethanol. 1H NMR (CD3OD) δ 7.40-7.22 (m, 5H), 4.69 (dd, J=7.8, 4.2 Hz, 1H), 3.41-3.34 (m, 3H), 3.22 (dd, J=13.8, 7.8 Hz, 1H), 2.25 (t, J=6.9 Hz, 2H). 13C NMR (CD3OD) δ 171.1, 161.3, 144.2, 129.5, 128.7, 127.3, 74.6, 48.9, 37.5, 34.7.

출처