반응 #4913

반응 방정식

2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepin-5-(4H)one

potassium phthalimide

→

white crystalline powder

수율 37.0%

2,3-Dihydro-2-[1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)ethyl-4-methylpyrido[3,2-f][1,4]oxazepin-5(4H)-one

수율 37.0%

용매

dimethylformamide

반응 조건

후처리

1. 1
   workup.WAITleft
2. 2
   workup.WAITstanding at room temperature overnight
3. 3
   기타Dimethylformamide was removed by rotary evaporation (80° C. vacuum pump)
4. 4
   세척washed with water (2×30 ml) and 2M potassium hydroxide (2×3 ml)
5. 5
   건조The organic layer was dried over anhydrous sodium sulfate
6. 6
   여과filtered
7. 7
   농축concentrated by rotary evaporation (70° C., water aspirator)
8. 8
   기타The 6.26 g of crude product was recrystallized from isopropyl alcohol

실험 절차

To a solution of 4.92 g (0.02 mole) of 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f]-1,4-oxazepin-5-(4H)one in 35 ml of dimethylformamide was added 7.55 g (0.041 mole) of potassium phthalimide. The mixture was stirred for 5 hr at 100° C. and left standing at room temperature overnight. Dimethylformamide was removed by rotary evaporation (80° C. vacuum pump). The residue was taken up in 100 ml of chloroform and washed with water (2×30 ml) and 2M potassium hydroxide (2×3 ml). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated by rotary evaporation (70° C., water aspirator). The 6.26 g of crude product was recrystallized from isopropyl alcohol to give 2.60 g (36%) white crystalline powder, m.p. 146°-47° C.

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