반응 #49103

반응 방정식

sodium borohydride

2-(dimethylamino)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methylpropanenitrile

phenyl lithium

D2

Racemic {1-[amino(phenyl)methyl]cyclopentyl}dimethylamine

→

title compound

수율 33.0%

(±)[2-Amino-1-({[(1,1-dimethylethyl)(dimethyl)silyl]oxy}methyl)-1-methyl-2-phenylethyl]dimethylamine

수율 33.0%

용매

methanol

dibutyl ether

THF

반응 조건

후처리

1. 1
   기타Chromatography (Biotage Horizon) to isolate the title compound

실험 절차

The title compound (930 mg, 33%) was prepared from 2-(dimethylamino)-3-{[(1,1-dimethylethyl)(dimethyl)silyl]oxy}-2-methylpropanenitrile D47 (2.1 g, 8.67 mmol), phenyl lithium (10.0 ml of a 1.8M solution in dibutyl ether, 18.0 mmol) in THF (30 ml) followed by sodium borohydride (830 mg, 26.0 mmol) in methanol (50 ml) in a similar manner to that described in D2. Chromatography (Biotage Horizon) to isolate the title compound was carried out using (i) 0 to 100% ethyl acetate/pentane, (ii) 100% ethyl acetate and (iii) 0 to 20% methanol/ethyl acetate. The product containing fractions were combined and evaporated. Mass spectrum (Electrospray LC/MS), API+: Found 323 (MH+), 306 (M−16). C18H34N2OSi requires 322. Ret. time 2.35-2.39 min. (broad peak).

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