반응 #49087

반응 방정식

1-[methyl(phenylmethyl)amino]cyclopentanecarbonitrile

phenyllithium

di-n-butylether

sodium borohydride

D2

Racemic {1-[amino(phenyl)methyl]cyclopentyl}dimethylamine

→

title compound

수율 47.0%

(±) -{1-[Amino(phenyl)methyl]cyclopentyl}methyl (phenylmethyl) amine

수율 47.0%

용매

THF

methanol

반응 조건

실험 절차

The title compound (3.90 g; 47%) was prepared from 1-[methyl(phenylmethyl)amino]cyclopentanecarbonitrile D28 (6.0 g; 28 mmol) and phenyllithium in di-n-butylether (16.21 ml of 1.9M solution; 30.8 mmol) in THF (60 ml), followed by reaction with sodium borohydride (3.2 g; 84 mmol) in methanol (60 ml) in a similar manner to that described in D2. Mass Spectrum (Electrospray LC/MS), API+: Found 295 (MH+). C20H26N2 requires 294. Ret. time 2.12 min.

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