반응 #49083

반응 방정식

sodium borohydride

2-(dimethylamino)-2-methylbutanenitrile

phenyllithium

D5

[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine

→

title compound

수율 93.0%

(±){1-[Amino(phenyl)methyl]-1-methylpropyl}dimethylamine

수율 93.0%

용매

THF

methanol

dibutylether

반응 조건

후처리

1. 1
   기타times 0.83 and 1.10 min.

실험 절차

The title compound (15 g, 93%) was prepared from 2-(dimethylamino)-2-methylbutanenitrile D23 (9.9 g, 0.078 mol) and phenyllithium in dibutylether (87.3 ml of a 1.8M solution; 0.157 mol) in THF (400 ml), followed by reaction with sodium borohydride (5.25 g, 0.138 mol) in methanol (450 ml) in a similar manner to that described in D5. Mass spectrum (Electrospray LC/MS), ES+: Found 207 (MH+). C13H22N2 requires 206. Ret. times 0.83 and 1.10 min.

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