반응 #49081

반응 방정식

sodium borohydride

sodium borohydride

2-methyl-2-(1-pyrrolidinyl)butanenitrile

phenyllithium

D5

[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine

→

title compound

수율 94.0%

(±)[2-Methyl-1-phenyl-2-(1-pyrrolidinyl)butyl]amine

수율 94.0%

용매

THF

methanol

dibutylether

반응 조건

후처리

1. 1
   workup.WAITat room temperature for 66 hours
2. 2
   기타times 0.78 and 1.06 min.

실험 절차

The title compound (13.4 g, 94%) was prepared from 2-methyl-2-(1-pyrrolidinyl)butanenitrile D21 (9.6 g, 0.063 mol) and phenyllithium in dibutylether (63 ml of a 2M solution; 0.126 mol) in THF (200 ml), followed by reaction with sodium borohydride (3.5 g, 0.092 mol) in methanol (200 ml) in a similar manner to that described in D5, except that after addition of the sodium borohydride stirring was continued with ice cooling for 0.5 hours then at room temperature for 66 hours. Mass spectrum (Electrospray LC/MS), ES+: Found 233 (MH+). C15H24N2 requires 232. Ret. times 0.78 and 1.06 min.

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