반응 #49079

반응 방정식

sodium borohydride

2-(dimethylamino)-2-ethylbutanenitrile

phenyllithium

D5

[2-methyl-1-phenyl-2-(1-pyrrolidinyl)propyl]amine

→

title compound

수율 88.0%

(±){1-[Amino(phenyl)methyl]-1-ethylpropyl}dimethylamine

수율 88.0%

용매

THF

methanol

dibutylether

반응 조건

실험 절차

The title compound (11.12 g, 88%) was prepared from 2-(dimethylamino)-2-ethylbutanenitrile D19 (8.05 g, 0.0575 mol) and phenyllithium in dibutylether (64 ml of a 1.8M solution; 0.115 mol) in THF (350 ml), followed by reaction with sodium borohydride (3.9 g, 0.103 mol) in methanol (300 ml) in a similar manner to that described in D5. 1H NMR (CDCl3) δ: 0.72 (3H, t, J=7.6 Hz), 0.97 (3H, t, J=7.6 Hz), 1.40-1.68 (4H, m), 1.70 (2H, br, m), 2.43 (6H, s), 4.09 (1H, s), 7.19-7.43 (5H, m).

출처