반응 #49063

ord-d4afe683d8ab4955ae9ad2edc26a9583

반응 방정식

[BH4-].[Na+]
sodium borohydride
CN(C)C1(C#N)CCCC1
1-(dimethylamino)cyclopentanecarbonitrile
[Li][c]1ccccc1
phenyllithium
O=C([O-])O.[Na+]
sodium bicarbonate
CN(C)C1(C(N)c2ccccc2)CCCC1
title product
CN(C)C1(C(N)c2ccccc2)CCCC1
(±){1-[Amino(phenyl)methyl]cyclopentyl}dimethylamine

반응 조건

상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    기타recooled to 0° C.
  2. 2
    온도the reaction mixture was cooled to 0° C.
  3. 3
    기타The organic phase was evaporated
  4. 4
    추출the resulting slurry extracted three times with DCM (3×150 ml)
  5. 5
    건조The combined extracts were dried (Na2SO4)
  6. 6
    기타evaporated
  7. 7
    기타to afford the crude product as a yellow oil (6.8 g)
  8. 8
    기타Half of the crude product was chromatographed on silica gel eluting with DCM-methanol (9/1) and DCM-2M ammonia in methanol mixtures (95/5 to 9/1 to 8/2)

실험 절차

To a solution of 1-(dimethylamino)cyclopentanecarbonitrile D1 (4 g; 28.9 mmol) in THF (30 ml) at −70° C. under argon was added dropwise a solution of phenyllithium in dibutylether (17.7 ml of a 1.8M solution; 32 mmol). The reaction mixture was allowed to warm to room temperature over 3 h., recooled to 0° C. and methanol added (30 ml) followed by careful addition of sodium borohydride (3.3 g; 87 mmol). After stirring at room temperature for 18 h, the reaction mixture was cooled to 0° C. and saturated aqueous sodium bicarbonate added. The organic phase was evaporated and the resulting slurry extracted three times with DCM (3×150 ml). The combined extracts were dried (Na2SO4), and evaporated to afford the crude product as a yellow oil (6.8 g). Half of the crude product was chromatographed on silica gel eluting with DCM-methanol (9/1) and DCM-2M ammonia in methanol mixtures (95/5 to 9/1 to 8/2) to afford the title product as a colourless oil (2.3 g). This oil was dissolved in diethyl ether (20 ml) and hydrogen chloride in diethylether was added at 0° C. After 20 min, the suspension was filtered to give the dihydrochloride salt (2.8 g) of the title product as a white solid. 1H NMR (DMSO) δ: 1.25 (2H, bs), 1.36 (2H, bs), 1.66-2.13 (4H, m), 2.64 (3H, s), 2.79 (3H, s), 4.92 (1H, bs), 7.32 (3H, m), 7.54 (2H, m), 8.95 (3H, bs), 10.82 (1H, bs).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US07745642B2uspto-grants-2010_06