반응 #49040

반응 방정식

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

methylamine

→

title compound

3-aminooxy-2,2,N-trimethyl-propionamide

용매

methanol

반응 조건

후처리

1. 1
   농축After the reaction mixture was concentrated under reduced pressure, dichloromethane
2. 2
   workup.ADDITIONwas added to the residue, and insoluble matter
3. 3
   여과was filtered
4. 4
   농축The filtrate was concentrated
5. 5
   기타the residue was purified by silica gel column chromatography

실험 절차

To 3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester (800 mg) obtained in Step A was added a 40% solution of methylamine in methanol (6 ml), and the mixture was stirred at 60° C. for 13 hours. After the reaction mixture was concentrated under reduced pressure, dichloromethane was added to the residue, and insoluble matter was filtered. The filtrate was concentrated, and the residue was purified by silica gel column chromatography to give the title compound (202 mg).

출처