반응 #49039

반응 방정식

diisopropyl azodicarboxylate

methyl hydroxypivalate

hydroxyphthalimide

triphenylphosphine

→

title compound

수율 33.6%

3-(1,3-dioxo-1,3-dihydro-isoindol-2-yloxy)-2,2-dimethyl-propionic acid methyl ester

수율 33.6%

용매

tetrahydrofuran

반응 조건

후처리

1. 1
   온도to warm gradually
2. 2
   농축concentrated under reduced pressure
3. 3
   기타The residue was roughly purified by silica gel column chromatography

실험 절차

To methyl hydroxypivalate (1.31 g, 9.89 mmol) were added tetrahydrofuran (40 ml), hydroxyphthalimide (3.23 g, 19.78 mmol) and triphenylphosphine (6.48 g, 24.73 mmol). After this solution was cooled to 0° C., diisopropyl azodicarboxylate (4.87 ml, 24.73 mmol) was added dropwise to the solution. While being allowed to warm gradually, the reaction mixture was stirred for 12 hours, and concentrated under reduced pressure. The residue was roughly purified by silica gel column chromatography to give the title compound (922 mg).

출처