반응 #49023

반응 방정식

isopropylamine

3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester

isopropylamine

→

N-(2-isopropylcarbamoyl-ethoxy)-acetimidic acid ethyl ester

수율 13.0%

용매

methanol

반응 조건

후처리

1. 1
   workup.STIRRINGthe mixture was stirred for 3 hours
2. 2
   기타a focused microwave synthesis system (Discover™, CEM) at 100 W
3. 3
   농축The reaction mixture was concentrated under reduced pressure
4. 4
   기타the residue was purified by silica gel column chromatography

실험 절차

To a known compound, 3-(1-ethoxy-ethylideneaminooxy)-propanoic acid methyl ester (CAS No. 97164-30-2, 300 mg, 1.585 mmol) were added methanol (3 ml) and isopropylamine (1.4 ml), and the mixture was stirred at 55° C. for 14 hours. Additional isopropylamine (1.0 ml) was added, and the mixture was stirred for 3 hours using a focused microwave synthesis system (Discover™, CEM) at 100 W. The reaction mixture was concentrated under reduced pressure, and the residue was purified by silica gel column chromatography to give N-(2-isopropylcarbamoyl-ethoxy)-acetimidic acid ethyl ester (46 mg, 13% yield).

출처