반응 #489848

반응 방정식

ethyl 2-(1,1-dioxidothiomorpholino)-4-oxo-4,5-dihydrofuran-3-carboxylate

7-azaindole-3-carboxaldehyde

piperidine

→

titled compound

수율 96.3%

Ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-(1,1-dioxidothiomorpholino)-4-oxo-4,5-dihydrofuran-3-carboxylate

수율 96.3%

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at ambient temperature
2. 2
   온도The mixture was refluxed for 2 days
3. 3
   여과The precipitate was collected by filtration
4. 4
   세척washed with hot ethanol
5. 5
   세척The solid was washed with hexane
6. 6
   기타then dried

실험 절차

To a solution of ethyl 2-(1,1-dioxidothiomorpholino)-4-oxo-4,5-dihydrofuran-3-carboxylate (0.027 g, 0.092 mmol) which similarly prepared according to the procedure described in the Example 74, Fourth step and 7-azaindole-3-carboxaldehyde (0.014 g, 0.092 mmol) in ethanol (0.5 mL), piperidine (0.00092 mL, 0.0093 mmol) was added at ambient temperature. The mixture was refluxed for 2 days. The precipitate was collected by filtration, washed with hot ethanol. The solid was washed with hexane then dried to afford the titled compound as solid (0.037 g, y. 47%).

출처