반응 #489832

반응 방정식

ethyl 2-[bis(2-methoxyethyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

7-azaindole-3-carboxaldehyde

L-proline

→

titled compound

수율 11.6%

Ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-[bis(2-methoxyethyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

수율 11.6%

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at ambient temperature
2. 2
   온도The mixture was refluxed for 2 days
3. 3
   여과the precipitate was collected by filtration
4. 4
   세척washed with ethanol
5. 5
   기타then dried

실험 절차

To a solution of ethyl 2-[bis(2-methoxyethyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate (0.30 g, 1.0 mmol) which similarly prepared according to the procedure described in the Example 4, First step and 7-azaindole-3-carboxaldehyde (0.15 g, 1.0 mmol) in ethanol (5.0 mL), L-proline (0.023 g, 0.20 mmol) was added at ambient temperature. The mixture was refluxed for 2 days. Cooled to ambient temperature, the precipitate was collected by filtration, washed with ethanol then dried to afford the titled compound as solid (0.048 g, y. 11%).

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