반응 #489793

반응 방정식

ethyl 2-(cyclohexylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate

7-azaindole-3-carboxaldehyde

hydrochloric acid

→

titled compound

수율 22.0%

Ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-(cyclohexylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate hydrochloride

수율 22.0%

용매

ethanol

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at ambient temperature
2. 2
   온도The mixture was refluxed for 4 h
3. 3
   여과the precipitate was collected by filtration
4. 4
   세척washed with ethanol and diisopropyl ether
5. 5
   기타then dried

실험 절차

To a solution of ethyl 2-(cyclohexylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate (0.019 g, 0.075 mmol) which similarly prepared according to the procedure described in the Example 2, First step and 7-azaindole-3-carboxaldehyde (0.011 g, 0.075 mmol) in ethanol (1.0 mL), 2M hydrochloric acid in ethanol (0.079 mL, 0.16 mmol) was added at ambient temperature. The mixture was refluxed for 4 h. Cooled to ambient temperature, the precipitate was collected by filtration, washed with ethanol and diisopropyl ether then dried to afford the titled compound (0.0070 g, y. 22%).

출처