반응 #489790

반응 방정식

ethyl 2[(2-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

7-azaindole-3-carboxaldehyde

piperidine

→

titled compound

수율 48.3%

Ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-[(2-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

수율 48.3%

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at ambient temperature
2. 2
   온도The mixture was refluxed for 12 h
3. 3
   여과the precipitate was collected by filtration
4. 4
   세척washed with ethanol and diisopropyl ether
5. 5
   기타then dried

실험 절차

To a solution of ethyl 2[(2-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate (0.14 g, 0.50 mmol) which similarly prepared according to the procedure described in the Example 2, First step and 7-azaindole-3-carboxaldehyde (0.073 g, 0.50 mmol) in ethanol (2.0 mL), piperidine (0.054 mL, 0.55 mmol) was added at ambient temperature. The mixture was refluxed for 12 h. Cooled to ambient temperature, the precipitate was collected by filtration, washed with ethanol and diisopropyl ether then dried to afford the titled compound (0.099 g, y. 48%).

출처