반응 #489786

반응 방정식

ethyl 2-(benzylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate

7-azaindole-3-carboxaldehyde

hydrochloric acid

→

titled compound

수율 56.0%

Ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-(benzylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate hydrochloride

수율 56.0%

용매

ethanol

반응 조건

후처리

1. 1
   온도was refluxed for 4 h
2. 2
   여과the precipitate was collected by filtration
3. 3
   세척washed with ethanol and diisopropyl ether
4. 4
   기타then dried

실험 절차

A solution of ethyl 2-(benzylamino)-4-oxo-4,5-dihydrofuran-3-carboxylate (0.026 g, 0.10 mmol) which similarly prepared according to the procedure described in the Example 2, First step and 7-azaindole-3-carboxaldehyde (0.015 g, 0.10 mmol) in 2M hydrochloric acid in ethanol (1.0 mL) was refluxed for 4 h. Cooled to ambient temperature, the precipitate was collected by filtration, washed with ethanol and diisopropyl ether then dried to afford the titled compound (0.024 g, y. 56%).

출처