반응 #489784

반응 방정식

ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

7-azaindole-3-carboxaldehyde

piperidine

→

titled compound

수율 24.4%

Ethyl 5-[(1H-pyrrolo[2,3-b]pyridin-3-yl)methylene]-2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate

수율 24.4%

용매

ethanol

반응 조건

후처리

1. 1
   workup.ADDITIONwas added at ambient temperature
2. 2
   온도The mixture was refluxed for 6 days
3. 3
   여과the precipitate was collected by filtration
4. 4
   세척washed with ethanol and hexane
5. 5
   기타then dried

실험 절차

To a solution of ethyl 2-[(4-chlorophenyl)amino]-4-oxo-4,5-dihydrofuran-3-carboxylate (0.18 g, 0.61 mmol) which similarly prepared according to the procedure described in the Example 2, First step and 7-azaindole-3-carboxaldehyde (0.088 g, 0.61 mmol) in ethanol (10 mL), piperidine (0.0044 mL, 0.044 mmol) was added at ambient temperature. The mixture was refluxed for 6 days. Cooled to ambient temperature, the precipitate was collected by filtration, washed with ethanol and hexane then dried to afford the titled compound (0.061 g, y. 23%).

출처