반응 #48876

반응 방정식

dimethylamine

THF

2-chloro-4,5-difluorobenzoic acid

(1-chloro-2-methylprop-1-en-1-yl)dimethylamine

triethylamine

→

title compound

수율 96.8%

2-Chloro-4,5-difluoro-N,N-dimethylbenzamide

수율 96.8%

용매

DCM

DCM

hydrochloric acid

반응 조건

후처리

1. 1
   기타separated
2. 2
   건조The organic layer was dried (MgSO4)
3. 3
   여과filtered
4. 4
   농축concentrated in vacuo

실험 절차

A solution of 2-chloro-4,5-difluorobenzoic acid (385 mg, 2.0 mmol) in DCM (5 mL) was treated with (1-chloro-2-methylprop-1-en-1-yl)dimethylamine (293 mg, 2.2 mmol) and stirred under argon for 1 hour. The mixture was then treated with triethylamine (0.56 mL, 4.0 mmol) and a 2M solution of dimethylamine in THF (1.2 mL, 2.4 mmol), and stirred for 18 hours. The mixture was diluted with DCM (5 mL) and 2M hydrochloric acid (4 mL) and separated. The organic layer was dried (MgSO4), filtered and concentrated in vacuo to afford the title compound (425 mg). The residue was used without further purification.

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