반응 #4886

반응 방정식

6-Hydroxy-5-quinolinecarboxylic acid

boron trifluoride

sodium bicarbonate

→

6-Hydroxy-5-quinolinecarboxylic acid methyl ester

반응 조건

후처리

1. 1
   기타to give finally a basic solution
2. 2
   추출The solution is extracted with chloroform
3. 3
   추출The chloroform extract
4. 4
   건조is dried over anhydrous sodium sulfate
5. 5
   농축concentrated
6. 6
   기타the residue is crystallized from a suitable solvent

실험 절차

6-Hydroxy-5-quinolinecarboxylic acid [as reported by Da Re, P. et al. in Ann. Chem. (Rome) 1970, 60(3), 215-24 (C.A. 73, 25338m)] is reacted with methanolic boron trifluoride solution for several hours. The resulting mixture is added to an aqueous solution of sodium bicarbonate to give finally a basic solution. The solution is extracted with chloroform. The chloroform extract is dried over anhydrous sodium sulfate and concentrated and the residue is crystallized from a suitable solvent.

출처