반응 #488480

ord-c8b5258a83f640ba85fb8104f7cea75c

반응 방정식

CCOC(=O)c1c([N+](=O)[O-])ccc(C)c1[N+](=O)[O-]
3-methyl-2,6-dinitro-benzoic acid ethyl ester
COC(OC)N(C)C
dimethoxymethyl-dimethylamine
→
CCOC(=O)c1c([N+](=O)[O-])ccc(C=CN(C)C)c1[N+](=O)[O-]
3-(2-dimethylamino-vinyl)-2,6-dinitro-benzoic acid ethyl ester
수율 58.0%

반응물

CCOC(=O)c1c([N+](=O)[O-])ccc(C)c1[N+](=O)[O-]
3-methyl-2,6-dinitro-benzoic acid ethyl ester
COC(OC)N(C)C
dimethoxymethyl-dimethylamine
—
ice water

시약

없음

용매

CN(C)C=O
DMF

반응 조건

온도
100°CELSIUS
상세 조건
See reaction.notes.procedure_details.

후처리

  1. 1
    여과the precipitate was collected via filtration
  2. 2
    세척washed with water

실험 절차

A mixture of 3-methyl-2,6-dinitro-benzoic acid ethyl ester (35 g, 0.14 mol) and dimethoxymethyl-dimethylamine (32 g, 0.27 mol) in DMF (200 mL) was heated at 100° C. for 5 h. The mixture was poured into ice water and the precipitate was collected via filtration and washed with water to give 3-(2-dimethylamino-vinyl)-2,6-dinitro-benzoic acid ethyl ester (25 g, 58%).

출처

DOI: 10.6084/m9.figshare.5104873.v1특허: US08741925B2uspto-grants-2014_06